Journal Browser

Go Edit a Special Issue


Special Issue Title:

Managing Coma in Critically Ill Patients: Clinical Neurophysiology

Deadline for manuscript submissions: 12 November 2021

Print Special Issue Flyer (22)

Special Issue Editor

  • Guest Editor

    Assit. Prof. Dr. Francesco LolliE-MailWebsite

    Laboratory Clinical Neurophysiology, Department of biomedical, experimental and clinical sciences "Mario Serio", University of Florence, Florence, Italy

    Interests: Clinical neurophysiology, Nervous system pathology, Neuroimmunology, Coma, Disorders of consciousness

Special Issue Information

Humans are not entirely different from animals in their experience to be self-aware; nevertheless, they are unique in being aware of our awareness. Conscious awareness is distantly facing medical electro-physiologic testing of the central and peripheral nervous system, which provides a functional and measurable view of the human brain, spinal cord, and nerves. While imaging techniques have superseded electro-physiologic testing for diagnosing structural brain lesions during disorders of consciousness, neurophysiology takes profit from studying brain function when the clinical evaluation is limited or difficult, particularly during sedation/altered self-awareness. Neurophysiology provides a real-time and continuous assessment of brain function not otherwise attainable. The change of these brain signals weight responses to therapeutic interventions, and it is pinned to the recovery of brain function or the progression of brain injury, the hallmark of prognostic tests. After the advances and standardization of critical care and neurosurgical techniques, survivors have better functional outcomes and fewer adverse outcomes, which must be predicted. For this prognostication, electro-physiologic testings are best applied as a complement to other methods in multimodal evaluations. While, on one side, patients with acute brain injury need a daily follow-up and treatment, on the other, the clinical practices, the social representations, and evidence-based recommendations are changings in an evolving field, and we need measurements of uncertainty and value in evidence. National and international societies that represent neuro-critical care produce guidelines, practice statements, and organized training with board certification, and the arena is now undergoing a fast scientific transformation. At this crossroads, particularly in clinical neurophysiology, an increasing number of research groups focus on better understanding, diagnosing, and prognostic tests of consciousness in acutely brain-injured patients, and in the evolutions of these disorders. This work has become of top clinical and ethical significance in revealing the underlying coma's mechanisms and showing more accurate prognosticators and treatments with a ground of insights gained from studying not only coma but anaesthesia, sleep, and evolution of disorders of consciousness such as vegetative and minimally conscious states. We are only now starting to understand the dynamic and complex interactions between brain regions required for the conscious state.

The prediction of the recovery, the duration of coma, or long term disability remain a matter of probability. The chances of recovery from coma mainly obviously depend on the severity and time of the brain injury. While the limitations of electrophysiological tests are that they still remain a relatively subjective measure of brain activity susceptible to artifacts, labor-intensive, and needing expertise, clear improvements are made in recent years. This volume intends to summarize and investigate these approaches.


Conscious awareness, Electro-physiologic testing, Neurophysiology,Acutely brain injury, prognostic, Neuro-critical care, Diagnosing, Coma

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. As of January 2021, Signa Vitae will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

Share This Special Issue

Published Papers (2 papers)

Open Access Special Issue

Acquired brain injuries: neurophysiology in early prognosis and rehabilitation pathway

Maenia Scarpino,Giovanni Lanzo,Bahia Hakiki,Raisa Sterpu,Antonio Maiorelli,Francesca Cecchi,Francesco Lolli,Antonello Grippo

DOI: 10.22514/sv.2021.132

(This article belongs to the Special Issue Managing Coma in Critically Ill Patients: Clinical Neurophysiology)

Abstract ( 2387 ) PDF (1.68 MB) ( 269 ) Full Text

Open Access Special Issue

Clinical approach to coma patients: tips and tricks

Winchana Srivilaithon,Sombat Muengtaweepongsa

DOI: 10.22514/sv.2021.230

(This article belongs to the Special Issue Managing Coma in Critically Ill Patients: Clinical Neurophysiology)

Abstract ( 6789 ) PDF (2.14 MB) ( 1939 ) Full Text

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time