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Special Issue Title:

Biomarkers and Action Strategies in Early and Subclinical Acute Kidney Injury

Deadline for manuscript submissions: 31 January 2022

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Special Issue Editor

  • Guest Editor

    Dr. Yacov ShachamE-MailWebsite

    Director, Cardiac intensive care unit, cardiology department, Tel-Aviv Sourasky medical center affiliated to the Sackler faculty of medicine, Tel-Aviv University, Tel-Aviv, Israel

    Interests: Acute myocardial infarction, Acute kidney injury, Acute renal impairment, Primary percutaneous coronary intervention

Special Issue Information

Acute kidney injury (AKI) is defined by a rapid increase in serum creatinine, decrease in urine output, or both. AKI occurs in approximately 10–15% of patients admitted to hospital, while its incidence in intensive care has been reported in more than 50% of patients. Progression to chronic kidney dysfunction or damage can occur over a longer period or follow AKI in a continuum with acute and chronic kidney disease. It is known today that AKI is not a single disease but rather a loose collection of syndromes as diverse as sepsis, cardio-renal syndrome, and urinary tract obstruction. While for more than a decade the sole indicator for acute renal dysfunction was serum creatinine elevation, in the past decade Biomarkers of kidney injury or stress were introduce and may serve as new tools for risk assessment and could possibly guide therapy. The approach to a patient with AKI depends on the clinical context and can also vary by resource availability. Although the effectiveness of several widely applied treatments is still controversial, evidence for several interventions, especially when used together, has increased over the past decade.

In this special issue we will be describing the epidemiology, pathophysiology, mechanism, prevention and diagnosis through biomarkers and action strategies in AKI in various settings such as cardiac surgery, intensive care unit, cardiology, nephrology and sepsis. We hope that clinical and experimental scientific reports will improve our understanding of this highly important entity and its management.


Acute kidney injury, Acute kidney disease, Tubular damage, Biomarkers, Nephron

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. As of January 2021, Signa Vitae will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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Published Papers (3 papers)

Open Access Special Issue

NGAL in trans-catheter aortic valve implantation on and off RenalGuard

Sapir Sadon,Yaron Arbel,Ariel Banai,Keren-Lee Rozenfeld,Phillipe Taieb,Aviram Hochstadt,Yacov Shacham,Shmuel Banai,Ariel Finkelstein,Ilan Merdler

DOI: 10.22514/sv.2021.048

(This article belongs to the Special Issue Biomarkers and Action Strategies in Early and Subclinical Acute Kidney Injury)

Abstract ( 1371 ) PDF (187.56 kB) ( 203 ) Full Text

Open Access Special Issue

Hydroxyethyl starch impairs renal water reabsorption in patients with cardiac shock

Zhi-Jie Yue,Zhan Shi,Zhuo Xie,Chun-Ming Li,Zhi-Yuan Guo,Meng Guo,Zhen-Guo Wang,Da-Jie Hao

DOI: 10.22514/sv.2021.136

(This article belongs to the Special Issue Biomarkers and Action Strategies in Early and Subclinical Acute Kidney Injury)

Abstract ( 1109 ) PDF (270.46 kB) ( 180 ) Full Text

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