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Special Issue Title:

Therapeutic hypothermia or targeted temperature management in the treatment of cardiac arrest and other life-threatening conditions

Deadline for manuscript submissions: 10 December 2021

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Special Issue Editor

  • Guest Editor

    Dr. Ozgur KARCIOGLUE-MailWebsite

    Professor of Dept. of Emergency Medicine, Univ. of Health Sciences, Istanbul Education and Research Hospital, Fatih, Istanbul, Turkey

    Interests: Cardiopulmonary resuscitation, Emergency management, Pain management, Trauma, Intensive Care Medicine

Special Issue Information

Sudden cardiac death and in- and out-of-hospital cardiac arrest (IHCA/OHCA) are common final pathways to death in most parts of the world, especially in the adult population. Only a minority of those patients who are successfully resuscitated with return of spontaneous circulation (ROSC) are able to survive to hospital discharge with a favorable neurologic status. The majority of in-hospital deaths from resuscitated victims of cardiac arrest have been attributed to neurologic injury. Current guidelines recommend consideration of therapeutic hypothermia (TH) for the management of comatose survivors of cardiac arrest. Standardized management of the victims of cardiac arrest which comprise organization of a TH program can be extremely difficult and necessitates a multidisciplinary team approach. Acute coronary syndromes are blamed for a significant percentage of cases with cardiac arrest, and feasibility of percutaneous coronary intervention in the emergency setting coupled with TH when indicated will pave the way to improved survival in this group of patients. Intracranial hemorrhages including subarachnoid hemorrhages and severe head injury also constitute other major indications for TH to provide neuroprotection. On the other hand, there is a considerable frequency of adverse effects linked to the procedure which can also constitute drawbacks. The objective of this special issue is to help healthcare providers conceptualize the current advances in implementation, indications, drawbacks, practical tips of TH for the practitioner, post-resuscitation care in emergency and critical care in this group of patients. Clinical research and review / state-of-the-art articles, case reports or case series on the procedure are welcomed.


Cardiac arrest, Therapeutic hypothermia, Adverse effects, Targeted temperature management, Intracranial hemorrhage, Resuscitation

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. As of January 2021, Signa Vitae will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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