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Special Issue Title:

Changes in the Critical Care in COVID-19: The efficacy of therapeutics and fluids, ventilation strategies, prone position and resuscitative maneuvers

Deadline for manuscript submissions: 15 December 2021

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Special Issue Editor

  • Guest Editor

    Dr. Ozgur KARCIOGLUE-MailWebsite

    Professor, Dept. of Emergency Medicine,Univ. of Health Sciences, Istanbul Education and Research Hospital, Fatih, Istanbul, Turkey

    Interests: Cardiopulmonary resuscitation, Emergency management, Pain management, Trauma, Intensive Care Medicine

Special Issue Information

There are currently no recommended specific treatments for the group with severe COVID-19, therefore, supportive treatment is essential. For example, many antivirals and antibiotics were launched as promising remedies against the disease, while little benefit has been proved so far. Likewise, “cytokine storm” has been targeted as a major determinant of severity of the clinical course and mortality, but few data have been published so far on interventions with significant benefit on the patients’ side. Respiratory failure is the most important killer of the patients with critical condition. High-flow nasal oxygenation and non-invasive ventilation can be sufficient for mild-to moderate cases. Expedient recognition and decisions for aggressive measures such as permanent control of airway and positive-pressure ventilation, along with administration of corticosteroids and some other agents, should be evaluated in more severe cases. Prone position is mostly associated with a better course than supine position in resuscitation of patients with critical condition. Extracorporeal membrane oxygenation (ECMO) is one of the last-chance measures to restore vital functions for the patient in extremis who do not respond to conventional interventions.

Sepsis and shock are also catastrophic events that should be recognized and managed expediently for favorable outcomes. If the mean arterial pressure (MAP) cannot be kept above 65 mmHg with intravenous (IV) hydration and lactate cannot be maintained below 2 mmol/L, vasopressor support should definitely be started. Development of coagulopathy is associated with high mortality in patients with COVID-19. Therefore, low molecular weight heparin (LMWH) should be used for prophylactic purposes.

Finally, there are numerous agents still debated in the medical community without robust evidence to support their use.

The objective of this special issue is to help healthcare providers conceptualize the current advances in implementation, indications, drawbacks, practical tips of the management strategies of COVID-19 and its complications for the practitioner in emergency and critical care. Clinical research and review / state-of-the-art articles, case reports or case series on the use of the agents and interventions in COVID-19 care are welcomed. 


COVID-19, Resuscitation, Treatment, Critical care, CPR, Emergency care, Shock, Extracorporeal membrane oxygenation, Prone position, Positive-pressure ventilation, Non-invasive ventilation

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. As of January 2021, Signa Vitae will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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