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Special Issue Title:

Anticoagulation Therapy in Heart Failure Subjects - Revealing The Enigma

Deadline for manuscript submissions: 15 February 2022

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Special Issue Editor

  • Guest Editor

    Dr. Alexandra ClementE-MailWebsite

    Institute of Cardiovascular Diseases “Prof Dr. I.M. Georgescu” Iasi, Romania

    Interests: Internal medicine, Cardiology, Cardiothoracic surgery

  • Guest Editor

    Dr. Cristian STĂTESCUE-MailWebsite

    "Grigore T. Popa" University of Medicine and Pharmacy, Internal Medicine, University Street, No. 16, 700115, Iaşi, Romania

    Interests: Internal medicine, Cardiology, Cardiothoracic surgery

  • Guest Editor

    Dr. Radu SASCĂUE-MailWebsite

    "Grigore T. Popa" University of Medicine and Pharmacy, Internal Medicine, University Street, No. 16, 700115, Iaşi, Romania

    Interests: Internal medicine, Cardiology, Cardiothoracic surgery

  • Guest Editor

    Dr. Larisa ANGHELE-MailWebsite

    "Grigore T. Popa" University of Medicine and Pharmacy, Internal Medicine, University Street, No. 16, 700115, Iaşi, Romania

    Interests: Internal medicine, Cardiology, Cardiothoracic surgery

Special Issue Information

Heart failure epitomizes a major public health issue, being linked to a substantial economic burden. In the past few decades, revolutionary advances have been made in the therapeutic management of this intricate syndrome, including both medical treatment and device therapy. Irrespective of these major progresses, mortality and morbidity in heart failure persists on being consistently high, similar to what was reported in the early 2000’s. Moreover, it is assumed that the number of heart failure-affected subjects will increase by 46% in the following 10 years. Therefore, the implementation of an appropriate patient care and the timely address of heart failure-related complications are more critical than ever.

It is largely known that heart failure is characterized by an increased risk of both systemic and pulmonary thromboembolic events, but the evidence regarding the benefits of anticoagulation therapy on clinical outcomes in subjects with heart failure and sinus rhythm is still controversial. Right ventricular dysfunction with venous stasis, hypercoagulability, and endothelial injury favor pulmonary thromboembolism, while cardiac chamber enlargement, adverse cardiac remodeling, and ventricular aneurysms promote left heart thrombosis and systemic embolism. Cardiac imaging helps identifying patients with heart failure at high risk of thrombotic events, providing incremental information over the need for antithrombotic therapy. Additionally, it helps diagnosing endocardial left ventricular thrombosis as well as left ventricular assist device thrombosis, long-term mechanical circulatory support devices representing a safe, powerful, and durable therapeutic option for end-stage heart failure subjects.

In the light of the above-mentioned data, this issue welcomes submissions on the subject of thrombotic events and heart failure, focusing on the mechanisms linking thrombosis and heart failure, the clinical trial evidence over the potential role of antithrombotic therapy in heart failure, and the contribution of cardiac imaging in implementing different anticoagulation regimens as well as in detecting cardiac and left ventricular assist device thrombosis. Original Research, Reviews, Mini-Reviews, Short Communications, Perspectives, and Case Report articles are welcomed.


Heart failure, Pulmonary thromboembolism, Left heart thrombosis, Anticoagulation regimens, Cardiac imaging, Left ventricular assist device

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. As of January 2021, Signa Vitae will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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Plan Papers (1 papers)

The role of multimodality imaging in assessing the need of anticoagulation therapy in heart failure subjects

Dr. Alexandra Clement

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