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Special Issue Title:

Sex-related differences in peri-operative and in critically ill patients

Deadline for manuscript submissions: 09 June 2022

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Special Issue Editor

  • Guest Editor

    Prof. Giovanni Landoni, MD E-MailWebsite

    Director of the Center for Intensive Care and Anesthesiology of San Raffaele Scientific Institute and Associate Professor at Vita-Salute San Raffaele University, Milan, Italy

    Interests: Intensive care and Anesthesia

Special Issue Information

Sex and gender differences are considered two emerging risk factors impacting morbidity and mortality. Sex, as the biological difference between men and women, influences physiology and pathophysiology of diseases. On the other hand, gender, as a social construct, may influence patient behaviour and clinician approach. Sex and gender disparities are reported in epidemiology, pathophysiology, clinical manifestations, and in response to treatment of diseases. They could be explained not only by genetic, epigenetic, and hormonal factors, but also by social behaviours such as smoking, alcohol, social attitude, sexual behaviour, and occupation.

The need for personalized medicine and patient-tailored treatment encourages physicians and researchers to consider sex and gender when dealing with disease prevention, diagnosis, and treatment. Cardiovascular diseases, cancer and metabolic syndrome, which are some of the most prevalent diseases worldwide, have been demonstrated to be strongly affected by sex and gender differences with a male prevalence. Instead, autoimmune diseases, pulmonary diseases, psychiatric and neurological diseases have a higher incidence in women compared to men. 

However, evidence assessing sex and gender differences among peri-operative patients and critically ill patients hospitalized in the emergency department and in the intensive care unit are still lacking. Variations in response to treatment of critically ill patients, according to sex and gender, should be more deeply investigated. Therefore, our journal is keen on publishing a special issue on sex and gender differences in the following settings: out of hospital and in-hospital emergencies; management of critically ill patients outside and inside the intensive care units; and perioperative setting.


Sex and gender differences, Peri-operative patients, Critically ill patients, Emergency department, Intensive care unit

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Signa Viate is an international peer-reviewed open access journal published by MRE Press. As of January 2021, Signa Vitae will change to a bimonthly journal. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1200. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

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Published Papers (1 papers)

Open Access Special Issue

Sex-related mortality differences in young adult septic shock patients

Alberto Zangrillo,Federica Morselli,Emanuela Biagioni,Roberta Di Stella,Irene Coloretti,Elena Moizo,Valentina Paola Plumari,Giacomo Monti,Giovanni Borghi,Andrea Salonia,Giada Almirante,Davide Maraggia,Massimo Zambon,Nicola Langiano,Agostino Roasio,Laura Pasin,Milena Mucci,Paolo Federico Beccaria,Nicola Pasculli,Martina Baiardo Redaelli,Ottavia Pallanch,Giulia Gallo,Giovanni Real,Marta Nava,Sophie Venturelli,Martina Tosi,Elena Munari,Maria Grazia Visconti,Silvia Perno,Massimo Girardis,Giovanni Landoni

Online publish date: 10 March 2022

DOI: 10.22514/sv.2022.017

(This article belongs to the Special Issue Sex-related differences in peri-operative and in critically ill patients)

Abstract ( 508 ) PDF (346.08 KB) ( 160 ) Full Text

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