Signa Vitae

Print ISSN: 1334-5605 | Online ISSN: 1845-206X

Official journal of the International Women in Intensive and critical care Network (iWIN, https://www.iwinideal.com/home/)

Signa Vitae (SV) is a peer-reviewed, open-access journal that aims to be an unbiased and permanent forum for the fields of emergency medicine, intensive care medicine, anesthesia and pain medicine. It focuses on the latest research advances in these fields, including Disease prevention, diagnose, treatment and prognosis, Disease etiology, pathophysiology, and molecular mechanisms, Health care, Medical personnel health, Facilities and equipment, Teaching and training, Organization and management, Information and techniques, Drug application, etc. As a tool for easier and more effective experiences and science sharing, SV aims to provide professionals dedicated to all these relevant fields with cutting-edge techniques and information.



Articles

Open Access

A year of impact: the best articles of 2024 in Signa Vitae

Fabio Guarracino,Ozgur Karcioglu,Eleni Moka,Orlando Rubén Pérez-Nieto,Matteo Borello,Giovanni Landoni,Joseph V. Pergolizzi,Todd C. Lee,Stephanie I. Rizk,Rob Mac Sweeney

DOI: 10.22514/sv.2025.139

Abstract ( 113 ) PDF (1.95 MB) ( 16 ) Full Text

Open Access

Metabolomics analysis and cytokine profiling in ARDS: rationale and methodology of standardized laboratory procedures for biological sample analysis

Gianluca Paternoster,Monica Carmosino,Luigi Milella,Serena Milano,Maria Ponticelli,Mariasilvia Sannicandro,Maria Carmela Izzi,Vittorio Carlucci,Alessandro Belletti,Edoardo Mongardini,Giacomo Monti,Giuseppe Giardina,Diego Palumbo,Erica Ronca,Brian Ferrara,Benedetta Chiodi,Federico Mattia Oliva,Noemi De Piccoli,Nora Di Tomasso

DOI: 10.22514/sv.2025.141

Abstract ( 106 ) PDF (1.59 MB) ( 17 ) Full Text

Open Access

Circadian rhythms on the median effective dose (ED50) of ciprofol in hysteroscopy: a prospective, double-blind, dose-response study

Xinpei Zhang,Yanhong Zhou,Wan Lei,Qian Wang,Yingjie Yang,Xinzhong Chen,Lili Xu

DOI: 10.22514/sv.2025.142

Abstract ( 102 ) PDF (4.33 MB) ( 8 ) Full Text

Open Access

Crush syndrome outcomes after earthquake

Mustafa İçer,Tuğçe Bayrak

DOI: 10.22514/sv.2025.137

Abstract ( 1997 ) PDF (2.74 MB) ( 15 ) Full Text

Open Access

Impact of increased emergency department ultrasound utilization on patient visit patterns

Chia-Ching Chen,Chi-Hao Chen,Chun-An Chou,Shao-Jen Weng,Yao-Te Tsai

DOI: 10.22514/sv.2025.143

Abstract ( 196 ) PDF (1.09 MB) ( 14 ) Full Text

Open Access

Peritonsillar bupivacaine infiltration reduces emergence delirium after tonsillectomy in children: a randomized, double-blind, controlled study

Hacer Sebnem Türk,Pınar Sayın,Mustafa Altınay,Leyla Kılınç,Bilge Türk,Ayşe Surhan Çınar,Sibel Oba

DOI: 10.22514/sv.2025.144

Abstract ( 103 ) PDF (686.74 kB) ( 14 ) Full Text

Open Access

Efficacy and safety of ciprofol compared to propofol during hysteroscopy: a single-centre, randomized, positive-controlled study

Guiling Xie,Wenbo Huang,Dashuo Peng,Qingtong Chen,Yanhui Li,Qi Xie,Sijin Peng,Wenyang Liu

DOI: 10.22514/sv.2025.145

Abstract ( 101 ) PDF (1.79 MB) ( 11 ) Full Text

Open Access

Admission rates and outcomes of elderly patients in emergency department observation units. A Spanish multicentre study

Francisco Javier Montero-Pérez,Inmaculada Bajo-Fernández,Juan González del Castillo,Guillermo Burillo-Putze,Cesáreo Fernández,Sira Aguiló,Aitor Alquézar-Arbé,Javier Jacob,Pere Llorens,Osvaldo Jorge Troiano Ungerer,Patricia Eiroa-Hernández,Patricia Parra-Esquivel,Mabel Coromoto Suárez Pineda,Martín Ruiz Grinspan,María Florencia Poblete Palacios,Matilde González Tejera,María Bóveda García,Mónica Veguillas Benito,Ferran Llopis,Rocío Muñoz Martos,Valle Toro Gallardo,Rodrigo Javier Gil Hernández,Jorge Pedraza García,Carmen Lucena Aguilera,María Dolores Pulfer,María Eugenia Rodríguez,Marta Iglesias Vela,María Rodríguez Romero,Alba Morant Gimenez,Òscar Miró,On behalf of the researchers of the SIESTA network

DOI: 10.22514/sv.2025.146

Abstract ( 110 ) PDF (4.74 MB) ( 11 ) Full Text

Published Ahead of Print

Open Access

Is ChatGPT able to interpret arterial blood gas analysis?A comparative cross-sectional study

Uğur Serkan Çitilcioğlu,Barış Arslan,Hatice Kaya Özdoğan,Hakan Yalım,Ümit Kara

Online publish date: 10 September 2025

DOI: 10.22514/sv.2025.138

Abstract ( 2344 ) PDF (979.29 kB) ( 43 ) Full Text

Open Access

Erector spinae plane block for breast surgery: an umbrella review of systematic reviews and meta-analyses

Burhan Dost,Alessandro De Cassai,Yunus Emre Karapinar,Mehmet Akif Yilmaz,Esra Turunc,Muzeyyen Beldagli,Mirac Selcen Ozkal Yalin,Ersin Koksal,Ali Ahiskalioglu,Serkan Tulgar

Online publish date: 12 August 2025

DOI: 10.22514/sv.2025.121

Abstract ( 3518 ) PDF (3.13 MB) ( 82 ) Full Text

Open Access

Comparative analysis of standard versus prolonged prone positioning in C-ARDS: outcomes on oxygenation and respiratory mechanics

Payam Rahimi,Tugba Yucel Yenice,Dicle Birtane,Sinan Asar,Zafer Cukurova

Online publish date: 30 May 2025

DOI: 10.22514/sv.2025.077

Abstract ( 4625 ) PDF (2.17 MB) ( 200 ) Full Text

Special Issues

Special issue title:

Optimization of Cardiovascular Dynamics in Critical Care Medicine and Anesthesiology

Keywords: Critical Care Medicine; Anesthesiology; Cardiovascular Dynamics; Hemodynamics

Editor: Prof. Dr. Athanasios Chalkias, MD, MSc, PhD, FESC, FAcadTM, FCP, FESAIC,Dr. Paraskevi Tselioti, MD, PhD

Submission deadline: 31 December 2025

Special issue title:

Acute Trauma: Immediate Interventions, Long-Term Impacts, Advancements, and Medico-legal Evaluation

Keywords: EMS; Trauma Management; Healthcare System Preparedness; Medico-Legal Evaluation

Editor: Prof. Dr. Giuseppe Basile, MD,Dr. Luca Bianco Prevot, MD,Dr. Vittorio Bolcato, MD

Submission deadline: 31 January 2026

Special issue title:

Advances in Emergency Cardiac Care

Keywords: Ischemic Heart Disease; Heart Failure; Arrhythmia; Defibrillation; PCI; Telemedicine; Resuscitation

Editor: Prof. Dr. Ozgur Karcioglu, MD, FEMAT,Assoc. Prof. Dr. Canan Akman, MD

Submission deadline: 01 March 2026

Special issue title:

Advances in the Diagnosis and Management of Sepsis and Septic Shock

Keywords: Diagnosis; Management; Sepsis; Septic Shock; Lactate Hypotension; Vasopressors

Editor: Prof. Dr. Ozgur Karcioglu, MD,Assoc. Prof. Dr. Feride Sinem AKGUN, MD,Assist. Prof. Dr. Betul AKBUGA OZEL, MD

Submission deadline: 01 May 2026

Special issue title:

2025 Annual Meeting of Taiwanese Society of Regional Anesthesia & Pain Management (TSRA-PM) in Conjunction with International Symposium of Regional Anesthesia Asia (RA Asia)

Keywords: Regional Anesthesia; Pain Medicine; Anatomy

Editor: Assoc. Prof. Dr. Jui-An Lin, MD, PhD,Assist. Prof. Dr. Kuo-Chuan Hung, MD,Enoch Yi-No Kang,Prof. Dr. Ke-Vin Chang, MD, PhD, CIPS, RMSK, ASRA-PMUC,Assoc. Prof. Dr. Wu Shao Chun, MD,Dr. Shang-Ru Yeoh, MD, MSc

Submission deadline: 01 August 2026

Special issue title:

Critical Interventions: Enhancing Emergency Medical Services through Interdisciplinary Research

Keywords: Emergency Medical Services; Interdisciplinary Research in EMS; Pre-hospital Care Technologies; Crisis Management in Healthcare; Psychological Aspects of EMS; Public Health and Emergency Services

Editor: Prof. Dr. Krzysztof Goniewicz, PhD,Prof. Dr. Ahmed M. Al-Wathinani, PhD

Submission deadline: 28 February 2025

Special issue title:

Advances in Obstetric Anaesthesia

Keywords: Obstetric Anaesthesia; Epidural Analgesia; Remifentanil-PCA; Labour and Delivery Outcomes; Quality Control in Perinatology and Obstetric Anaesthesia; ROTEM; Obstetric Haemorrhage; Preeclampsia

Editor: Prof. Tatjana Stopar Pintarič, MD, PhD, DEAA

Submission deadline: 31 December 2023

Special issue title:

Cardiothoracic anaesthesia and intensive care: current challenges and novelties

Keywords: cardiac anaesthesia, thoracic anaesthesia, intensive care, education, innovation, perioperative medicine, healthcare, outcomes, challenges

Editor: Dr. Marko Zdravkovic, MD, PhD

Submission deadline: 30 November 2022

Special issue title:

Selected papers from Korean Society of Emergency Medicine (KSEM) in 2021-2022

Keywords: Emergency medicine

Editor: Kyungwon Lee, MD, PhD,Young Duck Cho, MD, PhD

Submission deadline: 31 December 2022

Special issue title:

Medical Simulation - success in education, future of science

Keywords: medical simulation, emergency medicine, medical education

Editor: Tomasz Kłosiewicz, MD, MSc,Mateusz Puślecki, PhD

Submission deadline: 31 December 2022

To Be a Reviewer

If you would like to review a manuscript for Signa Vitae journal, please click “Review for SV” below to register at our submission website or log in our Online Peer Review system. Your name, contact details, and expertise will be automatically added to our database of reviewers.

Review for SV

Join Editorial Board

You are welcome to join our editorial board. Our journal produces and issues editorial board certificates for editorial board members, and the journal website will display the names and personal websites of editorial board members to help enhance their scientific influence. Members of the editorial committee are entitled to 1 free publication (editorial member’s or recommended paper) per year, and other articles over 2 can enjoy 30% discount of publishing fee.

Join Editorial Board

Editor-in-Chief

Prof. Giovanni Landoni, MD

Prof Giovanni Landoni, MD, is currently Full Professor and Residency Program Director of Anesthesia and Intensive Care Medicine at Vita-Salute San Raffaele University, Milan, Italy. He’s also Director of the Center for Intensive Care and Anesthesiology of San Raffaele Hospital in Milan, Italy. His strong clinical and research interests in intensive care and anesthesia resulted in more than 700 scientific publications in indexed journals, cited >20,000 times, h-index=75 on Scopus and 95 on Scholar, including randomized trials on NEJM, Lancet, and JAMA, and over 100 invitations in international congresses. He participated to 47 randomized controlled trials. Prof Landoni was Chief Investigator in successfully completed multicenter randomized clinical trials that randomized > 10,000 critically ill or perioperative patients over the last 10 years. He served as reviewer for over 50 journals (NEJM, JAMA, and The Lancet among others) and for foreign grant agencies, and he is member of the Editorial Board of several international journals.