Open Access

The dentist who sat on her chair and lost a leg. N2O?

GIOVANNI LANDONI,PASQUALE NARDELLI

DOI: 10.22514/SV132.112017.18

Abstract ( 4746 ) PDF (114.43 kB) ( 162 ) Full Text

Open Access

Human protein C concentrates in adult septic patients

GIOVANNI LANDONI,MARTINA CRIVELLARI,GIACOMO MONTI,CHIARA GERLI • PAOLO SILVANI,ALBERTO ZANGRILLO

DOI: 10.22514/SV32.102008.1

Abstract ( 3375 ) PDF (55.8 kB) ( 161 ) Full Text

Open Access

Human protein C concentrate in pediatric septic patients

GIOVANNI LANDONIĆ,GIACOMO MONTI,ALBERTO FACCHINI,FRANCESCO CAMA,ELENA BIGNAMI,LUCA CABRINI,FEDERICO PAPPALARDO,ALBERTO ZANGRILLO

DOI: 10.22514/SV51.042010.2

Abstract ( 3443 ) PDF (49.91 kB) ( 115 ) Full Text

Open Access

Administration of protein C concentrates in patients without congenital deficit: a systematic review of the literature

SIMONA SILVETTI,MARTINA CRIVELLARI,MARTA MUCCHETTI,DAIANA TADDEO,ANNALISA FRANCO,GIOVANNI LANDONI,ALBERTO ZANGRILLO

DOI: 10.22514/SV82.102013.2

Abstract ( 3911 ) PDF (61.77 kB) ( 137 ) Full Text

Open Access

Evolving from Past to Future: Facilitating SMART research

MARINA PIERI,RINALDO BELLOMO,ALBERTO ZANGRILLO,DARIO WINTERTON,GIOVANNI LANDONI

DOI: 10.22514/SV121.092016.1

Abstract ( 4605 ) PDF (375.41 kB) ( 173 ) Full Text

Open Access

Reevaluating the lower limit of renal autoregulation: does one size fit all?

Filippo D’Amico,Yuki Kotani,Matteo Borello,Matilda Colombo,Francesca Rumore,Francesco Papale,Rosario Losiggio,Giovanni Landoni

DOI: 10.22514/sv.2025.001

Abstract ( 17220 ) PDF (1.62 MB) ( 2372 ) Full Text

Open Access

The role of Macklin effect in management of ARDS: beyond spontaneous pneumomediastinum

Alessandro Belletti,Diego Palumbo,Michele De Bonis,Giovanni Landoni,Alberto Zangrillo

DOI: 10.22514/sv.2024.137

Abstract ( 5102 ) PDF (6.03 MB) ( 324 ) Full Text

Open Access

Inhalational vs. Intravenous anesthesia: is opposition helpful for clinicians?

Chiara Adembri,Alessandro Simonini,Elena Giovanna Bignami,Giovanni Landoni

DOI: 10.22514/sv.2026.013

Abstract ( 586 ) PDF (193 kB) ( 47 ) Full Text

Open Access

Anakinra for patients with COVID-19: an updated systematic review and meta-analysis

Giulio Cavalli,Paolo Navalesi,Giovanni Landoni,Andrey G. Yavorovskiy,Valery V. Likhvantsev,Alberto Zangrillo,Lorenzo Dagna,Giacomo Monti,Laura Pasin

DOI: 10.22514/sv.2023.025

Abstract ( 6104 ) PDF (2.48 MB) ( 212 ) Full Text

Open Access

Prone positioning in awake COVID-19 patients: a systematic review and meta-analysis

Laura Pasin,Lorenzo Dagna,Michela Consonni,Sabrina Boraso,Marina Munari,Carolina Soledad Romero García,Ekaterina Bulanjva,Giovanni Landoni

DOI: 10.22514/sv.2023.041

Abstract ( 4186 ) PDF (3.06 MB) ( 211 ) Full Text

Open Access

Melatonin as adjuvant treatment in COVID-19 patients. A meta-analysis of randomized and propensity matched studies

Krisztina Tóth,Eros Pilia,Giovanni Landoni,Davide Oreggia,Salvatore Giacomarra,Rosario Losiggio,Giacomo Maiucci,Iliyan Vlasakov,Andrey Yavorovskiy,Valery Likhvantsev,Andrea Székely,Remo Daniel Covello

DOI: 10.22514/sv.2023.076

Abstract ( 8825 ) PDF (1.9 MB) ( 302 ) Full Text

Open Access

Serious complications associated with nasogastric, orogastric or enteral tube misplacement over the decades: a systematic review

Federica Morselli,Rosario Losiggio,Corinne Caldei,Silvia Ferro,Andrey Yavorovskiy,Giovanni Landoni,Stefano Fresilli

DOI: 10.22514/sv.2025.015

Abstract ( 9043 ) PDF (2.55 MB) ( 365 ) Full Text

Open Access

Perioperative fenoldopam for the prevention of acute renal failure in non-cardiac surgery, randomized clinical trial

ANTONELLA MEMMO,ANDREA CAROZZO,GIOVANNI LANDONI,GRETA FANO,ORNELLA SOTTOCORNA,ELENA BIGNAMI,VERONICA GIACCHI,LAURA CORNO,SILVIO MAGRIN,ALBERTO ZANGRILLO

DOI: 10.22514/SV61.052011.2

Abstract ( 4210 ) PDF (58.54 kB) ( 145 ) Full Text

Open Access

Nesiritide and clinically relevant outcomes in cardiac surgery: a meta-analysis of randomized studies

GIULIA MAJ,GIOVANNI LANDONI,GIUSEPPE BIONDI-ZOCCAI,ELENA BIGNAMI,LUCA CABRINI,LUCA BURATTI,MASSIMILIANO GRECO,MASSIMO ZAMBON,ALBERTO ZANGRILLO

DOI: 10.22514/SV62.102011.2

Abstract ( 3567 ) PDF (143 kB) ( 146 ) Full Text

Open Access

Continuous infusion versus bolus injection of furosemide in pediatric patients after cardiac surgery: a meta-analysis of randomized studies

ALBERTO ZANGRILLO,LUCA CABRINI,GIUSEPPE G. L. BIONDI-ZOCCAI,GIACOMO MONTI,STEFANO TURI,IMAD SHEIBAN,ELENA BIGNAMI,GIOVANNI LANDONI

DOI: 10.22514/SV71.042012.3

Abstract ( 4907 ) PDF (117.22 kB) ( 195 ) Full Text

Open Access

Observed versus predicted hospital mortality in general wards patients assisted by a medical emergency team

LUCA CABRINI,GIACOMO MONTI,VALENTINA PAOLA PLUMARI,GIOVANNI LANDONI,STEFANO TURI,LAURA PASIN•PAOLO SILVANI,SERGIO COLOMBO,ALBERTO ZANGRILLO

DOI: 10.22514/SV71.042012.7

Abstract ( 3568 ) PDF (57.05 kB) ( 136 ) Full Text

Open Access

Decreasing mortality with drotrecogin alfa in high risk septic patients A meta-analysis of randomized trials in adult patients with multiple organ failure and mortality >40%

MASSIMILIANO GRECO,GIOVANNI LANDONI,LEDA NOBILE,GIACOMO MONTI,LAURA PASIN,CAETANO NIGRO,LUCA CABRINI,ALBERTO ZANGRILLO

DOI: 10.22514/SV91.042014.2

Abstract ( 3810 ) PDF (151.44 kB) ( 153 ) Full Text

Open Access

Methicillin-Resistant Staphylococcus Species in a cardiac surgical intensive care unit

MARINA PIERI,GIOVANNI LANDONI,MASSIMO ZAMBON,DAIANA TADDEO,ROBERTO ASCARI,MARCO COSTANTINI,FABRIZIO MONACO,ANNA MARA SCANDROGLIO,FEDERICO PAPPALARDO,TIZIANA BOVE,MARIA GRAZIA CALABRÒ,GIOVANNI MARINO,ALBERTO ZANGRILLO

DOI: 10.22514/SV102.122015.5

Abstract ( 3560 ) PDF (386.02 kB) ( 139 ) Full Text

Open Access

Efficacy and Safety of an Acute Pain Service among 10,760 Postoperative Patients

FRANCESCO DENI,GABRIELE FINCO,LAURA CORNO,GIOVANNI LANDONI,STEFANO TURI,ELEONORA COLNAGHI,LAURA COMOTTI,MARIO MUSU,RENATO MEANI,ALESSANDRA MELLO,VALERIA PEROTTI,NICOLA PASCULLI,LUIGI BERETTA,ALBERTO ZANGRILLO

DOI: 10.22514/SV121.102016.14

Abstract ( 3954 ) PDF (846.98 kB) ( 153 ) Full Text

Open Access

Unreported deaths in pediatric surgery and anesthesia: a national, twenty year report

ALESSANDRO PUTZU,EDOARDO CALDERINI,VALENTINA CAMARDA,GIOVANNI LANDONI

DOI: 10.22514/SV121.102016.17

Abstract ( 4256 ) PDF (471.47 kB) ( 150 ) Full Text

Open Access

Impact on the Regional Ambulance Services and Emergency Departments of the 2017 Freezing Rain in Milan

Giovanni Landoni,Omar Saleh,Maurizio Migliori,Carlo Picco

DOI: 10.22514/sv.2020.16.0010

Abstract ( 4981 ) PDF (246.12 kB) ( 187 ) Full Text

Open Access

Estimating SARS-CoV-2 infection fatality rate using data from one of the most affected areas worldwide

Giovanni Landoni,Carolina Faustini,Marilena Marmiere,Carolina Soledad Romero Garcìa,Annalisa Ruggeri,Alberto Zangrillo

DOI: 10.22514/sv.2021.149

Abstract ( 4816 ) PDF (171.64 kB) ( 209 ) Full Text

Open Access Special Issue

Sex differences in hospitalized COVID-19 patients

Rosaria Sofia,Martina Baiardo Redaelli,Olivia Belloni,Perla Cicero,Giovanni Landoni,Alberto Zangrillo

DOI: 10.22514/sv.2022.011

(This article belongs to the Special Issue COVID-19 in the Emergency Department: Epidemiology and changes throughout the pandemic)

Abstract ( 5611 ) PDF (2.38 MB) ( 190 ) Full Text

Open Access

Sex-related mortality differences in young adult septic shock patients

Alberto Zangrillo,Federica Morselli,Emanuela Biagioni,Roberta Di Stella,Irene Coloretti,Elena Moizo,Valentina Paola Plumari,Giacomo Monti,Giovanni Borghi,Andrea Salonia,Giada Almirante,Davide Maraggia,Massimo Zambon,Nicola Langiano,Agostino Roasio,Laura Pasin,Milena Mucci,Paolo Federico Beccaria,Nicola Pasculli,Martina Baiardo Redaelli,Ottavia Pallanch,Giulia Gallo,Giovanni Real,Marta Nava,Sophie Venturelli,Martina Tosi,Elena Munari,Maria Grazia Visconti,Silvia Perno,Massimo Girardis,Giovanni Landoni

DOI: 10.22514/sv.2022.017

Abstract ( 6843 ) PDF (346.31 kB) ( 312 ) Full Text

Open Access

One year health-related quality of life after discharge: a prospective cohort study among COVID-19 ICU survivors

Valery Likhvantsev,Giovanni Landoni,Artem Kuzovlev,Sergey Perekhodov,Nikolay Chaus,Maddalena Tucci,Mary Ann Belli,Kristina Kadantseva,Lubov Ermokhina,Mikhail Yadgarov,Levan Berikashvili,Valery Subbotin,Nataly Melnikova,Andrey Grechko

DOI: 10.22514/sv.2022.036

Abstract ( 6565 ) PDF (15.15 MB) ( 333 ) Full Text

Open Access

Esmolol as a cardioprotective agent to reduce low cardiac output syndrome after cardiac surgery

Giuseppe Crescenzi,Lucia Torracca,Michele Danilo Pierri,Filippo Capestro,Concetta Rosica,Federico Mattia Oliva,Giovanni Landoni

DOI: 10.22514/sv.2024.157

Abstract ( 4215 ) PDF (2.71 MB) ( 194 ) Full Text

Open Access

Remote ischemic preconditioning in non-cardiac surgery (PRINCE): a multinational, double blind, sham-controlled, randomized clinical trial

Massimiliano Greco,Gaetano Lombardi,Aidos Konkayev,Claudia Brusasco,Chong Lei,Agostino Roasio,Nerlep Rana,Hugo A. Mantilla-Gutierrez,Marco Micali,Gordana Gazivoda,Michela Gandini,Lian Kah Ti,Stefano Bosso,Maiya Konkayeva,Francesco Meroi,Lini Wang,Andrea Russo,Sergey Efremov,Giuseppe Fresta,Levan Berikashvili,Francesca Livi,Ivan Šitum,Fabio Guarracino,Elizaveta Leonova,Francesca Cavenago,Maria Shemetova,Edoardo Cristallo,Anastasia Smirnova,Lorenzo Schiavoni,Valerii Subbotin,Nicoletta Boffa,Giuseppe Giardina,Michele Introna,Cristina Nakhnoukh,Remo Daniel Covello,Marina Pieri,Stefano Turi,Valentina Ajello,Fabrizio Monaco,Francesco Corradi,Andrey Yavorovskiy,Valery Likhvantsev,Federico Longhini,Tiziana Bove,Rinaldo Bellomo,Giovanni Landoni,Alberto Zangrillo,Rosalba Lembo

DOI: 10.22514/sv.2024.151

Abstract ( 8308 ) PDF (8.98 MB) ( 343 ) Full Text

Open Access

A new portable and ready-to-use device for out-of-hospital non-invasive treatment of acute respiratory failure: preclinical validation

Eleonora Salurso,Federica Ciceri Negri,Giacomo Monti,Tommaso Scquizzato,Glauco Bordoni,Luca Cabrini,Katia Donadello,Giuseppe Santarpino,Gianfranco Beniamino Fiore,Alberto Redaelli,Filippo Consolo,Giovanni Landoni

Online publish date: 25 November 2025

DOI: 10.22514/sv.2025.185

Abstract ( 1571 ) PDF (6.68 MB) ( 78 ) Full Text

Open Access

Crying wolf in time of Corona: the strange case of ivermectin and hydroxychloroquine. Is the fear of failure withholding potential life-saving treatment from clinical use?

Pasquale Nardelli,Alberto Zangrillo,Gabriele Sanchini,Valery V Likhvantsev,Andrey G Yavorovskiy,Carolina Soledad Romero Garcia,Giovanni Landoni

DOI: 10.22514/sv.2021.043

Abstract ( 29662 ) PDF (241.72 kB) ( 3249 ) Full Text

Open Access

To everything there is a season: COVID-19 vaccination and thrombosis

Giovanni Landoni,Pasquale Nardelli,Alberto Zangrillo

DOI: 10.22514/sv.2021.075

Abstract ( 4679 ) PDF (142.06 kB) ( 254 ) Full Text

Open Access

Antiandrogen activity of drugs for COVID-19. The case of sabizabulin

Yuki Kotani,Beatrice Righetti,Mary Ann Belli,Giovanni Landoni

DOI: 10.22514/sv.2023.027

Abstract ( 4232 ) PDF (153.43 kB) ( 183 ) Full Text

Open Access

The renal effects of amino acids infusion

Rosario Losiggio,Martina Baiardo Redaelli,Alessandro Pruna,Giovanni Landoni,Rinaldo Bellomo

DOI: 10.22514/sv.2024.079

Abstract ( 6535 ) PDF (1.35 MB) ( 417 ) Full Text

Open Access

The arc of a life in critical care research—in memory of Professor Rinaldo Bellomo (1956–2025)

Giovanni Landoni,Martina Baiardo Redaelli

DOI: 10.22514/sv.2025.091

Abstract ( 3010 ) PDF (2.44 MB) ( 328 ) Full Text

Open Access

A year of impact: the best articles of 2024 in Signa Vitae

Fabio Guarracino,Ozgur Karcioglu,Eleni Moka,Orlando Rubén Pérez-Nieto,Matteo Borello,Giovanni Landoni,Joseph V. Pergolizzi,Todd C. Lee,Stephanie I. Rizk,Rob Mac Sweeney

DOI: 10.22514/sv.2025.139

Abstract ( 2234 ) PDF (1.95 MB) ( 154 ) Full Text

Open Access

Sevoflurane vs propofol in high risk cardiac surgery: design of the randomized trial “Sevo-Aifa”

GIOVANNI LANDONI,FABIO GUARRACINO,RUBIA BALDASSARRI,CLAUDIA CARIELLO ,CHIARA GERLI,GRETA FANO,FRANCESCO DE SIMONE,LUIGI CASSARÀ,ELENA FRATI,DEMETRIO PITTARELLO,LUIGI TRITAPEPE,ALBERTO ZANGRILLO

DOI: 10.22514/SV61.042011.6

Abstract ( 3682 ) PDF (55.24 kB) ( 166 ) Full Text